Tag: botanicals

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Six Targets For Optimal Weight Using Botanicals

 In my last post, I addressed the lifestyle changes that help to gently shift metabolism to a healthier state, which naturally results in achieving optimal weight. Excess weight is often a multi-faceted issue—not surprisingly, the best results are gained with a comprehensive approach. As I stated in my last post, I am not an advocate of a restrictive diet. Instead, I’ve found that providing the body with the nutrients it needs (including botanicals that enhance healthy metabolic function), in conjunction with a healthy and enjoyable lifestyle, results in almost effortless loss of surplus pounds.

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Protective Phytoestrogens Found In Botanicals

In my last post, I discussed the benefits of phytoestrogens, and how these plant compounds may help to regulate the effects of estrogen. While soy foods are perhaps the best-known phytoestrogens, there are a number of herbs with apparent phytoestrogenic properties that have a long history of use in herbal medicine. Current research has demonstrated the usefulness of these botanicals in protecting breast and prostate health.

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Phytoestrogens and Breast Health

In the quest to identify nutritional compounds that potentially influence breast cancer (and other hormonally driven cancers), phytoestrogens are among the best researched. The label “phytoestrogen” has been given to specific compounds in plants and foods that under certain conditions appear to have a modulatory effect on estrogen and other hormone receptors.

Plants contain a diversity of beneficial compounds, including a wide range of phenolic compounds, flavonoids, lignans, and phytosterols. Each phytochemical exerts multiple actions, both alone and in combination within and on target cells, including the epigenome. Abundant data indicates that these compounds act on estrogen receptors; for example, isoflavone and other compounds referred to as phytoestrogens have an ability to inhibit local estrogen synthesis and induce epigenetic changes.1 According to the most recent literature, phytoestrogens have demonstrated positive effects on breast cancer prognosis, including breast cancer recurrence and mortality in survivors of the disease.2 Continue reading “Phytoestrogens and Breast Health”

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Current Research into Botanicals and Cancer

As a follow-up to my post last week, Botanical Medicine: A Symphony in Harmony Against Cancer, I want to present some of the latest research into botanicals and cancer.

Researchers are investigating the potential of botanicals to treat all types of cancers, studying the use of natural compounds to prevent or reverse the process of carcinogenesis. For example, head and neck squamous cell carcinoma (HNSCC) is one of the most fatal cancers. Despite advances in the management of HNSCC, the overall survival for patients has not improved significantly due to advanced stages at diagnosis, high recurrence rate after surgical removal, and second primary tumor development. To develop approaches that can intervene at any stage of cancer development requires understanding of the crosstalk between cancer signaling pathways and networks to retain or enhance chemopreventive activity while reducing known toxic effects. Researchers are discovering that many natural dietary compounds have been identified as multiple molecular targets, effective in the prevention and treatment of cancer.1

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Botanical Medicine: How Herbs Represent A Symphony in Harmony Against Cancer

The world of Western conventional medicine is oriented to the ‘magic bullet’ paradigm, where the search for drugs relies on the concept of compounds that bind specifically to a single target and demonstrate a high degree of potency. Recently, though, this approach has broadened, with researchers suggesting that it is non-specific and relatively weak patterns of activity that may ultimately prove of greatest importance in drug discovery. Though research on multi-targeted drugs is still at an early stage, studies indicate that certain antipsychotic drugs, for instance, appear to be more effective when several types of receptors are targeted.1-3

Traditional herbal medicine recognized centuries ago that combining many plants delivers far better results than relying on a single plant. This is true both for supporting health and vitality and for treating imbalances and diseases. The multi-component nature inherent in medicinal herbs makes them particularly suitable for managing the multitude of issues that present in complex diseases such as cancer, and offers great potential for synergistic actions, including interactions between botanicals and the relationship of botanicals to conventional cytotoxic drugs such as chemotherapy and targeted agents.

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Do Antioxidants Prevent or Accelerate Cancer?

In a recent article published in Medscape, the authors state that antioxidants are not only useless in preventing cancer, but quite possibly promote cancer growth. The target audience for this article is primary care clinicians, oncologists, nurses, and other clinicians who care for patients at risk for cancer, with the purported goal of providing “medical news to primary care clinicians and other healthcare professionals in order to enhance patient care.”

I find this article disturbing, to say the least. Here’s why:

1) The article is blatantly biased. The authors point out only the few studies that have concluded negative results, while totally ignoring all of the positive studies—of which there are several hundred, or more. I do not understand how in good conscience they can skew the research findings in this way. Furthermore, I’m not certain of what they have to gain from this inaccurate representation of the total body of research available.

2) Their theory of antioxidants in relationship to cancer is completely wrong. The studies they use for their findings involve mostly synthetic forms of vitamin or mineral isolates. This is far removed from nature, and something I would never recommend. It’s essential to understand that the negative impact and possible increase in cancer incidence is related to a substance being a ‘PRO-OXIDANT’ and not an anti-oxidant. For example, high doses of vitamin C, K-3, beta-carotene, and E are all pro-oxidative when used as isolates, in high doses, and in certain conditions. It’s well established that smokers who take synthetic beta-carotene have an increased incidence of lung cancer. This does not mean that antioxidants cause cancer.

3) Details matter! It raises my ire when people use the word antioxidant in a general way. What specifically are they talking about? For example, the researchers for this article refer to the SELECT trial. Let’s explore this in a bit more depth to understand what the trial really reveals about antioxidants.

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