It’s important to reduce medication prescriptions for older adults (and everyone else). Why do we want to reduce medication prescriptions? Because prescription drugs are the third leading cause of death in the United States and Europe. Only heart disease and cancer cause more death.
In 2014 Peter Gøtzsche, a medical doctor and internationally known researcher and book author, wrote an article, called “Our prescription drugs kill us in large numbers.” In some ways his work is more relevant today than when he first wrote it. As Dr. Gøtzsche points out:
50% of those who die have taken their drugs correctly. The other half die because of human error, such as too high a dose or use of a drug despite contraindications.
Have you ever wondered how life on Earth has managed to survive in the midst of volcanos, ice ages and asteroids? The answer is adaptation. Humans are remarkably adaptable. We’ve been able to adjust to almost any condition on the planet, while continuing to thrive as a civilization.
Think about this:
No other species lives in such a variety of places, including the Arctic, in deserts, in jungles, at sea, or in barren wastelands.
No other species has the ability to eat and digest such a wide variety of foods.
No other species is able to reconstruct their living environment to the degree that humans do.
Charles Darwin said it well: “It is not the strongest or the most intelligent of the species that survives. It is the one that is most adaptable to change.”
Hormesis: The Key to Adaptation
The biological phenomenon of this adaptogenic quality of life is called “hormesis.” The principal pillars of my approach to health are to enhance adaptation, energy transfer efficiency, protection, and reproduction (hormonal health). Perhaps the most important of these is adaptation, but really, they are all interconnected. Everything is networked. Thus, the best approach to health is to support the networks of the body as a whole, to enhance robustness and our ability to auto-regulate and auto-organize at the molecular, cellular, and organ system levels.
This is why adaptogenic formulas are the first step in building and enhancing robust health, and the most important supplemental support you can provide to your body. Every other supplement you take should be secondary to adaptogenic formulations.
Our approach to health and healing is not a fixed line, but a circle that is alive and in constant motion. It is not functional, but rather responsive, so although everything in our body has a function, ultimately what makes us alive and human is how our bodies respond. Response implies a life-force that activates and regulates all components of energy transfer. This life-force is capable of listening to the “orchestra” (ie; network) and providing direction while constantly adapting. To function is robotic and programmed, while response is connected to wisdom and is alive.
Medicine today continues to view the body in a fragmented way, including body systems, parts, genes, and microbiomes. Very few people, particularly in the medical profession, see the whole, but we have complex diseases that are characterized as polygenic and multifactorial. We are therefore best served with medicines—specifically plant medicines—that are pleotrophic, gentle, nourishing, strengthening, and assist in normalizing, or auto-regulating.
Thinking Outside the Current Medical Model
Herbal formulations contain multiple components that dock to multiple target sites and synergistically exert beneficial effects throughout a wide range of pathways. Through many years of clinical practice, I’ve realized that it is neither possible or appropriate to try and fit herbal medicine into or alongside the current conventional model. That is why I developed the Mederi Care model as a new way of thinking and combining various approaches that is inclusive of both holistic and allopathic medicine. The soul of this approach, however, is rooted in botanical medicine, combined with nutritional supplementation, food as medicine, life-style modifications, and spiritual care. Once this foundation is in place, then it is appropriate to evaluate if more specific, “heroic” (ie; pharmaceutical) medicine is needed, and if so, where it fits within the whole systems, unitive approach.
The molecular pathways that govern human disease consist of molecular circuits that coalesce into complex, overlapping networks. These network pathways are presumably regulated in a coordinated fashion, but such regulation has been difficult to decipher using only reductionistic principles. The emerging paradigm of “network medicine” proposes to utilize insights garnered from network topology (ie; the static position of molecules in relation to their neighbors) as well as network dynamics (ie; the unique flux of information through the network) to understand better the pathogenic behavior of complex molecular interconnections that traditional methods fail to recognize.
Bioregulatory Systems Medicine
Bioregulatory Systems Medicine (BrSM) is a comprehensive, innovative approach in medicine. It embraces the complexity of diseases by supporting the general idea of autoregulation and addressing underlying dysregulating biological networks.
The objective of Bioregulatory Systems within the Mederi Care approach is to improve patient outcomes by supporting a patient’s autoregulatory capacity. This is accomplished through the Mederi Care toolboxes, specifically botanical and nutritional medicine, which is applied in a gentle, synergistic way. Botanical and nutritional medicine practiced within Mederi Care is primarily directed at enhancement of ‘Self-regulating Internal Community Networks,’ supporting and even directing, while allowing the freedom to improvise.
The poet and philosopher Mark Nepo says: “To be the best we can be, we have to meet the outer world with our inner world. I’ve always believed in the amazing resilience of the human spirit.” Nepo believed that life has been made just hard enough that we need one another. Through experiences of great suffering and great love, we are reduced to what is essential.
The most effective way to reduce the possibility of poor health and disease is to keep the root system healthy and robust. Adaptogenic herbs in combination have a synergistic and pleotropic effect.
Synergism Enhances the Actions of Plant Medicines
Synergistic plant medicines contain bioregulatory properties. Their actions are determined by both chemistry and synergy, as their biological activity often results from the additive or synergistic effects of their components.
“Synergy means behavior of whole systems unpredicted by the behavior of their parts.”
― Buckminster Fuller
These synergistic strategies can be much more comprehensive and broader in their scope of effects than single-component drugs. This concept is not new to science. Synergy is an ubiquitous phenomenon in nature, and is widely used in numerous scientific disciplines, including thermodynamics, biophysics, biochemistry, molecular biology, and neurobiology.
Herbal medicines are often combinations of botanical extracts that have additive or synergistic effects. For example, combining the four herbal (S. baicalensis, D. morifolium, G. uralensis and R. rubescens) extracts significantly enhanced their activity compared with extracts alone in a prostate cancer model.
It is important not to confuse synergistic effect with additive effect. Synergy occurs when two or more drugs/compounds are combined to produce a total effect that is greater than the sum of the individual agents while an additive effect is an add up of individual effects where each individual agent is not affecting the other (no interactions).
The synergy of biological effects of plants in medicine is well documented, and encompasses synergistic multitarget effects, physicochemical effects based on improved solubility, antagonization of resistance mechanisms, and elimination or neutralization of toxic substances. As such, multi-combination and/or multi-system low dose medications, preferably of natural origin, are well suited for the bioregulatory medical approach and offer the potential for a graded response to treatment.
Generally speaking, herbal and nutritional medicine within this model exhibits four fundamental advantages of a multicomponent, combinatorial strategy over a single-component strategy:
1. Synergistic effects target a wider range of information flow in disease-related biological networks;
2. Modest modulation allows for more efficient control of biological networks;
3. Low concentrations ensure higher safety of the whole combination;
According to Traditional Chinese medicine (TCM), every living thing is sustained by the balance of two opposing forces of energy, Yin and Yang. Together they make up Qi (pronounced ‘chee’), which is the vital energy that flows in, through and around the body.
Network Pharmacology: A New Way of Understanding Herbal Formulations
Network pharmacology stems from several pioneering works. The holistic theory and practice of TCM, as well as other herbal medicine systems, play a key role in the origin and rapid development of network pharmacology. The original hypothesis referring to the biological associations between TCM syndromes, herbal formula, and molecular networks was proposed in 1999 and 2002.
Network pharmacology has been used to study multiple protein/gene target diseases. It describes the relationship between biological systems, drugs, and diseases from the perspective of the network. This is consistent with the holistic pattern differentiation theory of TCM as well as Mederi medicine.
Mitochondrial Network Medicine
The mitochondrial network is constantly in a dynamic and regulated balance of fusion and fission processes, which is known as mitochondrial dynamics. Mitochondria make physical contact with almost every other membrane in the cell, thus impacting all cellular functions.
“Qi,” as noted above, describes energy-dependent body functions. This can broadly be correlated with mitochondria-energy dynamics.
The term adaptogen was first proposed in 1940 by a scientist from the USSR. Lazarev described Schisandra chinensis and other herbs as plant-derived adaptogens that non-specifically enhance human physiology.
Adaptogens are the material basis of the bodily response to the external environment and can act on the immune system and the stress response system, as shown below.
The non-specific response mode, especially the hormone response mode, occurs when homeostasis is not the driving force.
Schisandra Fortifies Mitochondrial (Qi) Antioxidant Status
Schisandra berry or Wu-Wei-Zi, meaning the “the fruit of five tastes” in Chinese, is a commonly used herb in TCM. Ancient Chinese herbalists noted the berry’s beneficial effect on the “Qi” of the five visceral organs. Schisandra is one of the main researched primary adaptogens that I use in adaptogenic formulations. It is perhaps my favorite adaptogen, but I believe combination formulas have many advantages over single herbs.
Schisandra berry is well-known for it’s “Qi-invigorating” properties. The herb has been shown to fortify mitochondrial antioxidant status, thereby offering the body generalized protection against noxious challenges, both of internal and external origin. Given the indispensable role of the mitochondrion in generating cellular energy, the linking of Schisandra chinensis berry extract (SCBE) to the safeguarding of mitochondrial function provides a biochemical explanation for its “Qi-invigorating” action.
SCBE is a potent adaptogen, and has been shown to improve disease and stress tolerance, while increasing energy, endurance, and physical performance.
SCBE is helpful in the treatment of neurological, cardiovascular, and gastrointestinal disorders. It has been shown to decrease fatigue, relieve insomnia, reduce obesity, and provide protection from mitochondrial dysfunction. SCBE stimulates immunity, acts as a tonic, and exerts antioxidant, anti-inflammatory, antiviral, anticancer, anti-aging, anti- diabetic, and liver- and skin-protecting activities.
Effects of Schisandra chinensis fruit extracts and their bioactive compounds in mitochondria.
SCBE has been shown to restore impaired mitochondrial function, acting as a mitoprotective agent. Studies show that schisandrin, the identified active ingredient in SCBE, restored cytochrome c oxidase activity, and protected the opening of mitochondrial permeability transition. Furthermore, schisandrin improved ATP production, citrate synthase activity, and the process of mitochondrial fusion and fission.
Recent studies investigating the various active compounds within schisandra identified a total of 78 compounds consisting of 13 prototype lignans and 65 metabolites (including isomers).
Combining schisandra extract with other adaptogens and tonic herbs provides hundreds to thousands of active compounds swimming together, bathing the cells and molecules throughout the body. Complex formulas no longer act like the single herb, but in an entirely new way. Think of an orchestra, and perhaps what a single member playing an instrument might sound like. Then consider the entire orchestra, and all of the instruments working in harmony. As a jazz musician and an herbalist with an interest in network pharmacology, this is a perfect analogy for the way that herbs work together when combined in appropriate formulations.
On Pubmed alone, there are now 30 articles illustrating the increasing interest in network pharmacology and traditional herbal medicine. Understanding network pharmacology and Bioregulatory Systems Medicineis the foundation of Mederi Care. I am grateful that this comprehensive, harmonious system of healing is gaining the recognition it deserves.
“When one tries to rise above nature, one is liable to fall below it.” – Sherlock Holmes
Exploring ‘Sherlock’s Corner’ of Mederi Medicine
From a wholistic perspective, cancer and other complex diseases require a deep investigation in several areas and involves the layering of various lenses, both macro and micro. Aptly, the Mederi Medicine approach has been greatly influenced by the problem-solving methods of the fictional detective, Sherlock Holmes. This is why I refer to the investigational component of Mederi Medicine as “Sherlock’s Corner”, to pay homage to Holmes’ logic.
Of equal relevance to the exploration, collection, and analysis of data in medicine is the understanding and application of hermeneutics. Hermeneutics is the science and method of interpretation, the process that helps us determine what is most relevant when considering the information within the context of a patient’s life story, which involves communication and relationship. Dr. Drew Leder explains that “Clinical medicine can best be understood not as a purified science, but as a hermeneutical enterprise: that is, as involved with the interpretation of (methodological) texts.” He suggests that the hermeneutics of medicine can be broken down into four text categories: “the “experiential text” as the patient’s experience of the illness; the “narrative text” as the history of the illness; the “physical text” as the objective examination of the patient’s body; the “instrumental text” as the construction by diagnostic technologies.” The information generated, when pooled together, can be useful in developing an understanding of the underlying disease, as well as a treatment plan. Leder further suggests that: “Certain flaws in modern medicine arise from its refusal of a hermeneutic self-understanding…in seeking to escape all interpretive subjectivity, medicine has threatened to expunge its primary subject–the living, experiencing patient.”
“We are living in an era of the most sophisticated technological advances, yet the treatment of cancer is paleolithic.” ~Azra Raza MD
The foundation of Mederi Medicine has always been to support people in thriving, not merely surviving, in the journey of life. Recently, I’ve been reading the book “Being Mortal: Medicine and What Matters in the End” by surgeon, professor, and public health researcher, Atul Gawande.
Dr. Gawande writes eloquently about what matters most in medicine. Now, more than ever, we need to hear these words of wisdom.
Health Optimization and Adaptogens –
An Effective Strategy Against Pathogens
In general, I
am astonished by how little attention is placed on the value and importance of
good health in our society. In the face of the current pandemic, with
underlying co-morbidities present in an estimated 60% of the population,
increasing the risk of death from complications, there is an even greater
urgency to educate our communities and urge our citizens to adopt the key
components to optimal health. For example, there is now a clear association
between diabetes and increased mortality and severity in COVID-19 pneumonia,
and ocular symptoms of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
These and many other underlying conditions can be successfully managed by
applying the fundamental building blocks to optimal health and wellness, which
include nutrition, botanical medicine, lifestyle, and diet. The more robust our
health at the molecular, cellular, and organ system levels, the better equipped
we are to resist and recover from disease.
More people are reaching a ripe old age
than ever before in history. In the early 1800s, life expectancy was a mere 45
years. But today, in Australia, Canada, Japan, and most European countries,
people can expect to live to 80 and beyond. If the trend continues, a majority
of babies born in these countries will live past their 100th birthday. But this
increase in longevity comes with some bad news. Although we manage to survive
longer than preceding generations, we often gain time without being healthier
in those extra years.
Difference Between Thriving and Surviving as We Age
Studies worldwide indicate that after age 60, most
people have at least one chronic disorder, such as heart disease or diabetes. A
recent population-based study in Sweden found that at age 80, only one of 10
individuals were living well and not suffering from either a chronic disease or
In the U.S. almost one-third of people older than 85 have
received an Alzheimer’s diagnosis, often combined with other types of dementia
such as that caused by vascular disease.1
with Our Modern Medicine Healthcare Model?
Modern Medicine faces fundamental challenges in that we are removing the human element and attempting to reduce everything to a single cause and effect. Given the functional interdependencies between the molecular components in a human cell, disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular and intercellular network that links tissue and organ systems.2