In the quest to identify nutritional compounds that potentially influence breast cancer (and other hormonally driven cancers), phytoestrogens are among the best researched. The label “phytoestrogen” has been given to specific compounds in plants and foods that under certain conditions appear to have a modulatory effect on estrogen and other hormone receptors.
Plants contain a diversity of beneficial compounds, including a wide range of phenolic compounds, flavonoids, lignans, and phytosterols. Each phytochemical exerts multiple actions, both alone and in combination within and on target cells, including the epigenome. Abundant data indicates that these compounds act on estrogen receptors; for example, isoflavone and other compounds referred to as phytoestrogens have an ability to inhibit local estrogen synthesis and induce epigenetic changes.1 According to the most recent literature, phytoestrogens have demonstrated positive effects on breast cancer prognosis, including breast cancer recurrence and mortality in survivors of the disease.2 Continue reading “Phytoestrogens and Breast Health”