Commentary on the Widely Disseminated Article entitled “Dietary
Supplement Use During Chemotherapy and Survival Outcomes of Patients with
Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG SO221)”
Published in the Journal of Clinical Oncology, December 2019
The DELCaP study, recently published in the Journal of Clinical Oncology evaluating
the use of dietary supplements during chemotherapy, has alarmed many patients
and raised troubling questions for health practitioners.
The purpose of the study was to evaluate associations between ‘antioxidant’ supplement
use and breast cancer outcomes in light of the widespread use of supplements
during cancer therapies and the ongoing debate over concerns that antioxidants
could reduce the cytotoxic effects of reactive oxygen species (ROS) generated
by chemotherapy agents. The authors claim that the use of dietary supplements
before and during chemotherapy is associated with an increased risk of
recurrence and, to a lesser extent, death.1
Continue reading “A Clinician’s Perspective on the Use of ‘Antioxidant’ Dietary Supplements During Chemotherapy: Exploring the ‘Body of Evidence’ in Favor of Supporting the Health of Breast Cancer Patients”
In my two previous posts on these health, I discussed the potential problems associated with diagnosing and treating them. As I stated in my first post, thyroid problems are frequently under diagnosed, primarily because of inadequate testing and incomplete understanding of the complexities of thyroid function. At the same time, they are often treated in ways that further compromise function.
Continue reading “Connecting the Dots in Adrenal-Thyroid Health (Part 3 of 3)”
In the quest to identify nutritional compounds that potentially influence breast cancer (and other hormonally driven cancers), phytoestrogens are among the best researched. The label “phytoestrogen” has been given to specific compounds in plants and foods that under certain conditions appear to have a modulatory effect on estrogen and other hormone receptors.
Plants contain a diversity of beneficial compounds, including a wide range of phenolic compounds, flavonoids, lignans, and phytosterols. Each phytochemical exerts multiple actions, both alone and in combination within and on target cells, including the epigenome. Abundant data indicates that these compounds act on estrogen receptors; for example, isoflavone and other compounds referred to as phytoestrogens have an ability to inhibit local estrogen synthesis and induce epigenetic changes.1 According to the most recent literature, phytoestrogens have demonstrated positive effects on breast cancer prognosis, including breast cancer recurrence and mortality in survivors of the disease.2 Continue reading “Phytoestrogens and Breast Health”
On our recent trip to Israel, my wife Jen and I appreciated the abundance of healthful foods, including fresh pomegranate juice. Pomegranate juice is a popular beverage throughout the country, and everywhere we went, there were stands offering freshly prepared juice, either straight up or mixed with fresh orange juice. We looked forward to watching the vendors juice the ripe pomegranates, and then enjoyed sipping the delicious ruby red beverage.
Continue reading “The Many Health Benefits of Pomegranates”
To enhance my work as a clinician, I spend an average of two hours every day researching and compiling data in the fields of health, nutrition, botanical medicine, dietary supplements, and conventional medicine. This includes evaluating studies on innovative pharmaceutical drug therapies, particularly in the realm of oncology.
From time to time, I’ll be sharing a few of the week’s highlights with you. I hope you will find these interesting, and perhaps the information will be beneficial for you or someone you know.
Continue reading “Recent Highlights In Health Research”
I thoroughly enjoy mushrooms—in fact, I actually crave them. It’s likely that this craving can be traced to my Italian culinary heritage—we often add mushrooms to pizza and pasta dishes, but we find them equally delicious in soups, stir-fries, and salads. In addition to the common white button mushroom, we also search for maitake, morel, oyster, portobello, shiitake, and any other unique varieties that appear at our local farmer’s market or natural foods store.
Continue reading “Enjoy Mushrooms For Better Health”