Statin-Associated Myopathy and Mitochondrial Impairment

If we knew what it was we were doing, it would not be called research, would it?” Albert Einstein

Part One

I’m often asked if I think statin drugs are useful. Of course it’s important first to address the issue of cholesterol levels which statin drugs are used to control. I recently wrote a blog entitled “What can Centenarians teach us about cholesterol levels and longevity – It isn’t what you think” in which I provided substantial evidence questioning the current guidelines regarding what is actually a healthy total cholesterol level.

As far as statins go, my opinion is that if people are willing to be involved in their own healthcare by adopting a comprehensive approach to health optimization—which includes a healthy diet and lifestyle, the support of appropriate botanical and nutritional medicines, and a positive attitude—then I see little to no need for statin drugs. 

However, if you do feel the need to take a statin, then I will provide you with essential supportive care to both mitigate the adverse effects of statins and to potentiate them, so that a reduced amount might be sufficient.

Continue reading “Statin-Associated Myopathy and Mitochondrial Impairment”

Potatoes: The Humble Food That Tops All Other Super Foods

People love the idea of ‘super foods,’ and I’m commonly asked my thoughts about everything from goji berries to blue-green algae. Some super foods, like chia seeds and coconut oil, are foods that I recommend. Others, like blue-green algae—sourced from a lake polluted by agricultural runoff—are supplements that I obviously do not advise taking. But even the super foods I like and recommend don’t compare to the humble potato. The humble potato is nutrient dense, and not only is it good for you, it’s good for the health of the planet.

Potatoes have gotten a bad rap, with many people thinking that they’re fattening and devoid of nutritional value. But potatoes have a long history of nourishing humankind. In Ireland, people based their diets on nutrient rich potatoes for hundreds of years. 

Continue reading “Potatoes: The Humble Food That Tops All Other Super Foods”

WHOLE GRAINS, WHOLE PLANET: SUSTAINABLE FOOD IN THE FACE OF CLIMATE CHANGE

Grains are the most important source of food on our planet, providing nearly 50% of the caloric needs of cultures around the world. Fortunately, grains also happen to be among the least intensive foods to produce. Along with environmental sustainability, grains provide significant health benefits.

According to the 2015 Dietary Guidelines Advisory Committee, “consistent evidence indicates that, in general, a dietary pattern that is higher in plant-based foods, such as vegetables, fruits, whole grains, legumes, nuts, and seeds, and lower in animal-based foods is more health promoting and is associated with lesser environmental impact.” 1

Continue reading “WHOLE GRAINS, WHOLE PLANET: SUSTAINABLE FOOD IN THE FACE OF CLIMATE CHANGE”

Are Smartphones and Social Media Our #1 Threat to a Healthy Life?

 I discovered that technology’s quest towards the unknown
requires us to accumulate more and more control,
whereas growing in virtue requires an altogether different capacity:
more and more surrender.
~Nipun Mehta

Believe it or not, I do not own smartphones. I’m not averse to technology. But I spend so much time on my computer engaged in research and writing that when I take a break from my work, I truly take a break. I want to be fully present in life without the temptation of looking at my smartphone. Instead of focusing on my phone, I walk down the street enjoying my surroundings and smiling at people as I pass by. If I need directions, I ask someone directly, engaging in real communication with another human being.

Along with the benefit of being engaged in life, removing myself from the seductive pull of technology frees up time for my mind to wander, which is essential to creative thought and wellbeing.

On average, people in the U.S. check their smartphones 46 times per day (up from 33 times per day in 2014). And it’s worse for users in the U.K. A study by Nottingham Trent University found that adults ages 18-33 checked their smartphones 85 times a day, or once every 10 minutes—and they don’t even know they are doing it.1

We are giving up our uniqueness as individuals, becoming mere facts and statistics plugged into technology and artificial intelligence. Many believe this is a good thing and will improve our lives. But as we create smarter robots that are increasingly human-like, humans are at the same time becoming more robot-like. What happens to the human spirit in this race for technology?

I am deeply concerned about the physical, emotional, and spiritual price we are paying for technology, which is advancing at a speed that is impossible for us to adjust to. Drug addiction, drug overdosing, and suicide are epidemic in our society, and feelings of isolation are a primary cause. Social interaction is emerging as perhaps the single most important factor to a long, healthy and happy life, but overdosing on technology leads to isolation, not interaction.

My new motto has become: “Together we heal.” Continue reading “Are Smartphones and Social Media Our #1 Threat to a Healthy Life?”

Understanding Neutrophil to Lymphocyte Ratio (Part 2): Research Demonstrating its Role as a Valuable Prognostic Marker in Cancer

Understanding Neutrophil to Lymphocyte Ratio (Part 2): Research Demonstrating its Role as a Valuable Prognostic Marker in Cancer

A large body of research (as well as my clinical observations) point to chronic inflammation as a powerful force in the initiation, growth, and spread of cancer. As a result, an essential component of my protocol for health includes addressing inflammation.

As I discussed in part 1 of this series, there are three points to consider when evaluating the role of inflammation in cancer. First, a chronic inflammatory state can initiate cancer development. Second, it’s important to discover and address the root cause of the inflammation—for example, pathogenic (chronic infection), life-style, stress, and/or poor dietary habits. And third, recognize that the cancer itself creates inflammation—as the cancer energy mutates and gains intelligence, it manipulates the immune system, creating a pro-inflammatory micro-environment favorable to cancer growth.

Research indicates that the systemic manifestations of inflammation can provide a valuable biomarker for prognosis and treatment stratification. In particular, numerous studies indicate that a simple indicator of systemic inflammation—based on neutrophilia and/or lymphocytopenia—can provide prognostic information in a wide range of cancer types. In particular, the value of one index (the dNLR) derived from total white cell and neutrophil counts, is enabling large retrospective studies to be carried out.

Neutrophil to Lymphocyte Ratio May Be a Predictor of Mortality in All Conditions

White blood cell (WBC) count is one of the useful inflammatory biomarkers in clinical practice. For example, even if WBC is within normal range, subtypes of WBC including N/L ratio may predict cardiovascular mortality.

N/L ratio is a readily measurable laboratory marker used to evaluate systemic inflammation. There are many different conditions that can affect N/L ratio, including hypertension, diabetes mellitus, metabolic syndrome (1), left ventricular dysfunction, acute coronary syndromes, valvular heart disease, abnormal thyroid function tests, renal or hepatic dysfunction, known malignancy (2,3,4), local or systemic infection, previous history of infection (<3 months), inflammatory diseases, and any medication related to inflammatory conditions.

Here’s one example of how the N/L ratio can be useful as part of the evaluation of a specific cancer and the treatment protocol: not only N/L ratio but also mean platelet volume, red cell distribution width (5), platelet distribution width, CRP, uric acid and gamma-glutamyl transferase (6) are easy markers to evaluate the prognosis of colon cancer patients (7). However, one should keep in mind that N/L ratio itself alone without other inflammatory markers may not give exact information to clinicians about the prognosis of colon cancer patients. (8,9).

Continue reading “Understanding Neutrophil to Lymphocyte Ratio (Part 2): Research Demonstrating its Role as a Valuable Prognostic Marker in Cancer”

The ETMS Diet: A Mediterranean-Inspired Diet Customizable for Optimum Health

Med diet photo

I’ve spent the past four decades researching and refining the diet that I’ve found best supports health and healing. The Eclectic Triphasic Medical System (ETMS) approach to diet is based on traditional wisdom and supported by scientific research. It is sensible, balanced, diverse, nutrient-rich, and delicious.

In my last post, I addressed the currently popular ketogenic diet, which many people have adopted for weight loss. Other people pursue the carbohydrate-restrictive, fat-laden keto diet with the hope of curing cancer. Neither of these outcomes is supported by research.

Guidelines for the ETMS Diet: An Optimal Nutrition Plan

The primary guidelines of the ETMS diet are based on a pesca-flexa-vegetarian diet, which I describe in detail here: https://www.donnieyance.com/pesca-flexa-vegetarianismContinue reading “The ETMS Diet: A Mediterranean-Inspired Diet Customizable for Optimum Health”